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On CanadaPetCare, we carry a myriad of parasite prevention treatments for dogs, out of which two products have gained the utmost popularity among our customers. These two products are Simparica Trio and NexGard Spectra.

As we bring to light that these two terrific flea, tick, and worm treatments are most trusted by dog parents across the world, the question arises: how do you pick one from two that have already been touted as the best?

In this blog, we have explained the difference between Simparica Trio and NexGard Spectra to help you pick the very best for your precious pooch.

Difference Between Simparica Trio and NexGard Spectra

Simparica Trio and NexGard Spectra are vet-recommended chewable treatments for common dog parasites. Both of these products protect dogs from a wide range of pesky pests such as fleas, ticks, heartworms, and intestinal worms.

Simparica Trio from Zoetis Pet Care is a once-a-month chewable designed for your dog’s defense. Formulated with a trio of powerful ingredients, a single chew of Simparica Trio for dogs covers fleas, ticks, heartworms, roundworms, and hookworms. It also controls five tick species, including, gulf coast ticks, American dog ticks, Lone star ticks, deer ticks, and Brown dog ticks, and as a result, prevents Lyme disease in dogs.

On the other hand, NexGard Spectra is an upgraded version of Boehringer Ingelheim’s popular NexGard portfolio. It is a broad-spectrum protection for dogs, effective against fleas, ticks, mange, mites, heartworms, and intestinal worms like roundworms, hookworms, and whipworms. NexGard Spectra is also known to prevent flea tapeworm infestations in dogs.

The main difference between the two is their formulation, ingredients, mechanism of action, and time taken to begin working. Simparica Trio is formulated using Sarolaner, Moxidectin, and Pyrantel, while NexGard Spectra contains Afoxolaner and Milbemycin Oxime. Simparica Trio starts killing fleas within 4 hours of administration, whereas, NexGard Spectra begins killing fleas within 6-8 hours of administration.

Have a look at this table of comparison between Simparica Trio and NexGard Spectra for a simpler interpretation.

Simparica Trio vs. NexGard Spectra

So, Which One is Better, NexGard Spectra or Simparica Trio?

Nexgard Spectra and Simparica Trio perform likewise as flea, tick, and worm treatments for dogs. Both are equally recommended by veterinarians and trusted by dog owners. However, NexGard Spectra does provide some additional protection against mange and whipworms as compared to Simparica Trio. So, if these parasites are a concern for your dog, NexGard Spectra may be better for your dog. Otherwise, the Simparica Trio is just as effective too. In any case, do not forget to take your vet’s opinion on the suitability of the product for your dog.

FAQs About Simparica Trio and NexGard Spectra

Can I give my dog Simparica Trio and Nexgard Spectra together?

As you can see, both Simparica Trio and NexGard Spectra are equally effective products for fleas, ticks, worms, and heartworms in dogs, but it is not recommended to give both treatments at once. This may also cause side effects due to drug interactions.

Is NexGard Spectra the same as Simparica Trio?

NexGard Spectra and Simparica Trio share many similarities when it comes to parasite protection against fleas, ticks, heartworms, and intestinal worms like hookworms and roundworms. However, they are not exactly the same due to the differences in their formulation, mode of action, flavor, and cost. NexGard Spectra is a beef-flavored chewable, whereas Simparica Trio is a liver-flavored chewable. Furthermore, NexGard Spectra also provides additional protection against whipworms, mange, and mites.

Can I use NexGard Spectra instead of Simparica Trio?

Simparica Trio and NexGard Spectra both are safe and effective treatments for dogs and puppies from 8 weeks of age. So, it is safe to use either of them for your dog. But if you are planning to switch to Simparica Trio from NexGard Spectra, do consult your veterinarian to check if the transition is suitable for your dog.

[Also Read] 10 Tips for A Successful Online Vet Consultation

Why is Simparica Trio expensive as compared to NexGard Spectra?

Both Simparica Trio and Nexgard Spectra are composed of different ingredients, have different modes of action, and are produced by different manufacturers; hence, we cannot compare the prices. You can find both products on CanadaPetCare at the lowest prices and special discounts.

Choose The Best for Your Dog!

As a dog parent, it is your core responsibility to keep your dog safe from deadly parasites. Routine treatment with Simparica Trio or NexGard Spectra is a great way of doing so.

Simparica Trio for Dogs

Keep your dog safe from fleas, ticks, heartworms, and intestinal worms with a single palatable liver-flavored chewable every month.

Nexgard Spectra for Dogs

Protect your dog from fleas, ticks, mites, mange, heartworms, and intestinal worms using this monthly, easy-to-give, beef-flavored chewable.


Jesse McDaniel is an animal activist that raises concerns and spreads awareness regarding pet health issues. She is also a self-proclaimed pet lover who tends to support many pet shelters, assisting them with supplies and medical aid on a regular basis.