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All dogs should be protected against heartworms, but it doesn’t mean you can disregard other parasites like fleas, ticks and intestinal worms. There are several products available in the market that offer protection against different parasites. Pet parents often confuse themselves regarding which treatment to use for their dogs. It is important to know which product is best suited for your fur babies.

Advantage Multi and Simparica Trio are a couple of popular broad-spectrum treatments that offer protection against a variety of parasites. But which of these two will work for your dog; you need to find this out before trying them on your pet.

This blog will give a thorough comparison of these two products that differ in terms of mode of action, composition and target organisms.

Advantage Multi for Dogs    

Advantage Multi for Dogs is a monthly topical broad-spectrum treatment that provides protection against five major parasites. It prevents heartworm disease, treats and controls intestinal worms, controls sarcoptic mange, kills adult fleas, and treats flea infestations. It contains two active ingredients- imidacloprid and moxidectin. The unique combination of these components aids in the protection against parasites.

Simparica Trio for Dogs

Simparica Trio for dogs is a simple monthly oral treatment, in the form of liver-flavored chews. It protects against heartworm disease, roundworms, and hookworms. Simparica Trio also kills fleas within 4 hours and gets rid of five major tick species- Gulf Coast ticks, American Dog ticks, Lone Star ticks, Deer ticks, and Brown Dog ticks. It comprises three components, each having a unique mode of action. Sarolaner eliminates ticks and fleas, while Pyrantel is a component that controls and treats intestinal worm infestations. Moxidectin, on the other hand, prevents heartworm disease.

Similarities Between Advantage Multi and Simparica Trio

Both Advantage Multi and Simparica Trio share some similarities. Some of them drawn out are-

  1. Both products should be administered every month to obtain effective results.
  2. These products also provide protection against intestinal worm infestations like adult hookworms and roundworms.
  3. Both the products kill adult fleas and prevent heartworm diseases in dogs.
  4. Neither product shall be administered to lactating, pregnant, or breeding dogs.

[Also Read] Simparica Trio Vs Nexgard Spectra – Which is Better?

Differences Between Advantage Multi and Simparica Trio

  1. One of the major differences between Advantage Multi and Simparica Trio is the mode of administration. The former is a topical treatment while the latter is administered orally.
  2. Simparica Trio protects against hookworms and roundworms while Advantage Multi offers multi-worm protection since it kills whipworms in addition to hookworms and roundworms.
  3. Advantage Multi for Dogs treats and controls sarcoptic mange while Simparica Trio does not protect against mange.
  4. Simparica Trio eliminates 5 tick species- Gulf Coast ticks, American Dog ticks, Lone Star ticks, Deer ticks, and Brown Dog ticks; while Advantage Multi for dogs does not protect against ticks.

Simparica TRIO and Advantage Multi Comparison Table Chart

Frequently Asked Questions   

How long do these products take to work?

Simparica Trio kills fleas within 4 to 8 hours of treatment. Advantage Multi for dogs kills fleas within 4 hours of application. Wait for 24 hours before bathing your pet. For year-round protection, continue to treat your pet with either of these treatments every month throughout the year.

Can I use these products for heartworm prevention?

Before administrating Advantage Multi or Simparica Trio, get your pet screened for an existing heartworm infection. Both Simparica Trio and Advantage Multi for dogs prevent heartworm disease.

[Also Read] Common Heartworm Prevention Mistakes

Is it safe to use these if my dog is pregnant?

The safety of Advantage Multi for dogs and Simparica Trio has not been evaluated in pregnant, breeding and lactating dogs. Consult your vet before using any of these treatments on your dog.

What should I do if I missed a dose of these products?

If you miss a dosage of Simparica Trio or Advantage Multi for dogs, give a dose immediately and continue with the monthly dosing schedule.

How to determine the dosage of the treatment?

The dosage of the treatment depends on the weight of your dog. Select the product according to the weight of your dog. Both these products are available in different weights and sizes.


When it comes to heartworm protection, both Simparica Trio and Advantage Multi are equally effective. If flea and tick infestation is a reason for your worry, Simparica Trio is the product for you. In comparison to Simaprica Trio, Advantage Multi treats an additional worm infestation (whipworms).

The choice between these two products depends on the convenience of use and your canine’s preference (topical or oral). In case of any confusion, it is always better to consult with a veterinarian who will help you choose the best treatment for your pet.


Jesse McDaniel is an animal activist that raises concerns and spreads awareness regarding pet health issues. She is also a self-proclaimed pet lover who tends to support many pet shelters, assisting them with supplies and medical aid on a regular basis.